Nagesh Kolishetti, Ph.D.

Nagesh Kolishetti, Ph.D., is an Assistant Professor in the Department of Immunology and Nano-Medicine at the College of Medicine, FIU. Kolishetti completed his Master's in Chemistry and Ph.D. in the area of Polymer Science. Kolishetti's postdoctoral training was focused on the areas of Nanomedicine and Drug Delivery. Before joining FIU, Kolishetti was leading the chemistry division at Partikula LLC, a startup company focused on developing mitochondrial-targeted therapeutics, platinum prodrugs, and metabolic modulators. Kolishetti's current research focus is in the areas of polymer science and nanomedicine with applications in cancer and HIV/AIDS.

Education and Training

• Masters (M.Sc.): Chemistry, University of Hyderabad, Hyderabad, 1998-2000
• Doctoral Work (Ph.D.): Polymers, Indian Institute of Science, Bangalore, 2000-2006.
• Post-Doctoral Fellow: University of Massachusetts, Lowell, MA, 2006-2008.
• Post-Doctoral Fellow: Brigham and Women’s Hospital, Harvard Medical School, Boston 2008-2010.
• Research Affiliate: David H Koch Integrative Cancer Research Institute at Massachusetts Institute of Technology, Cambridge, USA, 2008-2010.
• Complex Carbohydrate Research Center, University of Georgia, Athens, 2010-2014.

Publications

Full publication list: https://scholar.google.com/citations?hl=en&user=DAgZQRYAAAAJ

• Surnar, B.; Basu, U.; Banik. B.; Ahmad, A.; Marples, B.; Kolishetti, N.; and Dhar, S. “Nanotechnology-mediated crossing of two impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection" Proc. Natl. Acad. Sci., 2018, 115, E12333-E12342.
• Surnar, B.; Kolishetti, N.; Basu, U.; Ahmad, A.; Goka, E.; Marples, B.; Kolb, D.; Lippman, M.; and Dhar, S. “Reduction of cisplatin induced ototoxicity without compromising its antitumor activity” Biochemistry, 2018, 57, 6500-6513. (co-first author)
• Pathak, R. K.; Basu, U.; Ahmad, A.; Sarkar, S.; Kumar, A.; Surnar, B.; Ansari, S.; Wilczek, K.; Ivan, M. E.; Marples, B.; Kolishetti, N.; and Dhar, S. “A designer bow-tie combination therapeutic platform: An approach to resistant cancer treatment by simultaneous delivery of cytotoxic and anti-inflammatory agents and radiation" Biomaterials, 2018, 187, 117-129.
• Banik, B.; Wen, R.; Marrache, S.; Kumar, A.; Kolishetti, N.; Howerth, E.; Dhar, S. “Core hydrophobicity tuning of a self-assembled particle results in efficient lipid reduction and favorable organ distribution” Nanoscale, 2018, 10, 366-377.
• Pathak, R. K.; Wen, R.; Kolishetti, N.; and Dhar, S. "A Prodrug of two approved drugs, cisplatin and chlorambucil, for chemo war against cancer" Mol. Cancer Ther., 2017, 16, 625-636.
• Pathak, R. K.; Kolishetti, N.; Dhar, S. “Targeted nanoparticles in mitochondrial medicine” WIREs Nanomed. Nanobiotechnol., 2015, 7, 315-329.
• Liden, P.V.; Kolishetti, N.; Hudlikar, M. H.; Boons, G.-J. “Exploring strain-promoted 1,3-dipolar cycloadditions of end functionalized polymers” (co-first author) Chem. Eur. J., 2014, 20, 8753–8760.
• Liden, P.V.; Kolishetti, N.; Boons, G.-J. “Multifuctionalization of polymers by strain-promoted cycloadditions” Macromolecules 2013, 46, 7759–7768.
• Marrache, S.; Pathak, R. K.; Darley, K. L.; Choi, J. H.; Zaver, D.; Kolishetti, N.; Dhar, S. “Nanocarriers for Tracking and Treating Diseases” Curr. Med. Chem., 2013, 20, 3500-3514.
• Dhar, S.; Kolishetti, N.; Lippard, S. J.; Farokhzad, O. C. “Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo” Proc. Natl. Acad. Sci., 2011, 108, 1850-1855. (co-first author)
• Kolishetti, N.; Dhar, S.; Valencia, P. M.; Lin, L.; Karnik, R.; Langer, R.; Lippard, S. J.; Farokhzad, O. C. “Engineering of self-assembled nanoparticle platform for precisely-controlled combination drug therapy” Proc. Natl. Acad. Sci., 2010, 107, 17939-17944.
• Mamo, T.; Moseman, E. A.; Kolishetti, N.; Morales, C. S.; Shi, J.; Kuritzkes, D. R.; Langer, R.; von Andrian, U.; Farokhzad, O. C. “Emerging nanotechnology approaches HIV/AIDS treatment and prevention” Nanomedicine, 2010, 5, 269-285.
• Kolishetti, N.; Faust, R. “Structure-reactivity scales in carbocationic polymerizations” Macromolecules, 2008, 41, 9025-9029.
• Kolishetti, N.; Gupta, D; Kabra, D.; Narayan, K. S.; Ramakrishnan, S. “Tunable two-colour patterning of MEHPPV from a single precursor” J. Mater. Chem., 2007, 17, 1682-1686.
• Kolishetti, N.; Ramakrishnan, S. "Grafting functional handles on to MEHPPV-possible application for sensing" Synth. Metals, 2005, 155, 320-323.

Patents

• Kolishetti, N.; Dhar, S.; Langer, R.; Lippard, S. J.; Farokhzad, O. C. “Particles for multiple agent delivery”, PCT Int. Appl. 2011, WO 2011084620 A2 20110714.
• Lippard, S.J.; Dhar, S.; Farokhzad, O. C.; Kolishetti, N.; Gu, F. X. “Nanostructures for drug delivery”,  U.S. 2013, US 8603532 B2 20131210

Research Support

Florida International University Foundation, 2018-2020 HWCOM-FIU Pilot Grant     
Role: PI
The goal of this project to develop polymeric nano-formulations for delivery of antiretroviral drugs.

Editorial Service

Associate Editor of Frontiers in Nanotechnology, Biomedical Nanotechnology (2019- Present)