The Dimitroff Laboratory is led by principal investigator, Charles J. Dimitroff, Ph.D., a professor of Translational Medicine at Florida International University’s Herbert Wertheim College of Medicine. The lab is located on the 4th floor of Academic Health Center 5.
Dr. Dimitroff has studied the nature of lectin – carbohydrate interactions and their impact in inflammation and cancer for the last 26 years. He has an expertise in glycobiology studies relating to tumor biology and adaptive immunity and is qualified to perform pre-clinical research investigating how glycome-related molecules contribute to the pathogenesis of inflammation and cancer. He conducts both in vitro and in vivo experiments designed to characterize the identity and function of lectins and their carbohydrate-binding ligands on leukocytes and cancer cells.
His experimental systems include the use of:
- Carbohydrate inhibitors
- MALDI-TOF-TOF MS/MS
- “Home grown” selectin/ galectin-human Fc chimeras and glycosyltransferase mutant cell lines/mice as glycobiological tools to identity and characterize selectin/galectin ligands functioning in inflammation, tumorigenesis, metastasis, tumor immune evasion and lymphomagenesis
- Native human tissues/cells as sources to isolate the relevant immune/cancer cells.
Dr. Dimitroff's laboratory is designed to train high school, undergraduate and graduate students. and post-doctoral fellows ith an emphasis to build academic metrics and career advancement.