Selected Publications

Full bibliography available at the National Library of Medicine, National Center for Biotechnology Information  

  1. Esteban-Lopez M, Agoulnik AI. Diverse functions of insulin-like 3 peptide. Journal of Endocrinology, 2020 doi:
  2. Ceyhan Y, Zhang M, Guo J, Sandoval CG, Vacher J, Kaftanovskaya EM, Agoulnik AI, Agoulnik IU. Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice. PLoS One. 2020;15(5):e0233163. doi: 10.1371/journal.pone.0233163. eCollection 2020. PubMed PMID: 32413098; PubMed Central PMCID: PMC7228085.
  3. Kaftanovskaya EM, NgHH, Soula M, RivasB, Myhr C, Ho BA, Cervantes B, Shupe TD, Devarasetty M, HuX, Xu X, Patnaik S, Wilson KJ, Barnaeva E, Ferrer M, Southall N, Marugan JJ, Bishop CE, Agoulnik IU, Agoulnik AI. Therapeutic effects of a small molecule agonist of the relaxin receptor, ML290 in liver fibrosis. FASEB J. 2019; doi: 10.1096/fj.201901046R
  4. De Toni L, Agoulnik AI, Sandri M, Foresta C, Ferlin A. INSL3 in the muscolo-skeletal system. Mol Cell Endocrinol. 2019; 487:12-17. doi: 10.1016/j.mce.2018.12.021. Epub 2019 Jan 6. Review. PMID: 30625346.
  5. Ng HH, Esteban-Lopez M, Agoulnik AI. Targeting the relaxin/insulin-like family peptide receptor 1 and 2 with small molecule compounds. Mol Cell Endocrinol. 2019 May 1;487:40-44. doi: 10.1016/j.mce.2018.12.013. Epub 2018 Dec 24. Review. PubMed PMID: 30590098; PMCID: PMC6451876.
  6. FerlinA, De Tony L, Agoulnik AI, Lunardon G, Armani A, Bortolanza S, Blaauw B, Sandri M, Foresta C. Protective role of testicular hormone INSL3 from atrophy and weakness in skeletal muscle. Endocrinol., 2018, doi: 10.3389/fendo.2018.00562. PMCID: PMC6102074.
  7. Wilson KJ, Xiao J, Chen CZ, Huang Z, Agoulnik IU, Ferrer M, Southall N, Hu X, Zheng W, Xu X, Wang A, Myhr C, Barnaeva E, George ER, Agoulnik AI*, Marugan JJ*. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. European Journal of Medicinal Chemistry, 2018. V. 156, p. 79-92, PIMD: 30006176.
  8. Bezhaeva T, de Vries MR, Geelhoed WJ, van der Veer EP, Versteeg S, van Alem CMA., Voorzaat1 BM, Eijkelkamp N,. van der Bogt KE, Agoulnik AI, van Zonneveld A-J, Quax PHA, Rotmans JI. Relaxin receptor deficiency promotes vascular inflammation and impairs outward remodeling in arteriovenous fistulas. FASEB J. 2018 Jun 8:fj201800437R. doi: 10.1096/fj.201800437R., PMID: 29882709.
  9. Kaftanovskaya EM, Soula M, MyhrC, Ho BA, Moore SN, Yoo C, Cervantes B, How J, Marugan J, Agoulnik IU, Agoulnik AI. Human Relaxin Family Peptide Receptor 1 (RXFP1) is Activated by Relaxin and Small Molecule Agonist ML290 in Transgenic Mice. Minor Revisions, Journal of Endocrine Society. 2017, Endocr. Soc. (2017) 1 (6): 712-725. doi: 10.1210/js.2017-00112.
  10. Kocan M, Sarwar M, Siwek C, Ang SA, Xiao J, Marugan JJ, Hossain MA, Samuel CA, Hutchinson D, Agoulnik AI, Bathgate RAD, Summers RJ. ML290, a small molecule agonist, is an allosteric biased ligand at RXFP1 expressed in human recombinant and primary cells. Scientific Reports. 2017, Jun 7;7(1):2968. doi: 10.1038/s41598-017-02916-5.
  11. Agoulnik AI, Agoulnik IU, Hu X, Marugan JJ. Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1, Br J Pharmacol. 2016 Oct 23. doi: 10.1111/bph.13656. PMID: 27771940.
  12. Ivell R, Agoulnik AI, Anand-Ivell R. Relaxin-like peptides in male reproduction - a human perspective, Br J Pharmacol. 2016, doi: 10.1111/bph.13689, PMID: 27933606.
  13. Hu X, Myhr C, HuangZ, Xiao J, Barnaeva E, Ho BA, Agoulnik IU, FerrerM, Marugan JJ, Southall N, Agoulnik AI. Structural insights into the activation of human relaxin family peptide receptor 1 by small molecule agonists. Biochemistry, 2016 Mar 29;55(12):1772-83. doi: 10.1021/acs.biochem.5b01195. PMID:26866459.
  14. Kaftanovskaya EM, Huang Z, LopezC, Conrad K, Agoulnik AI. Conditional Deletion of the Relaxin Receptor Gene in Cells of Smooth Muscle Lineage Affects Lower Reproductive Tract in Pregnant Mice. Biology of Reproduction, 2015 Apr;92(4):91. doi: 10.1095/biolreprod.114.127209. PMID:25715795.
  15. Huang Z, Myhr C, Bathgate RAD, Ho B, Bueno A, Hu X, Xiao J, Southall N, Barnaeva E, Agoulnik IU, MaruganJ, Ferrer M, Agoulnik AI. Activation of Relaxin Family Receptor 1 from different mammalian species by relaxin peptide and small molecule agonist ML290. Frontiers in Endocrinol. 2015, doi: 10.3389/fendo.2015.00128. PMID:26347712; PMCID: PMC4538381