Srinivasan Chinnapaiyan, Ph.D.
Immunology and Nano-Medicine
Office: AHC1 417B
Srinivasan Chinnapaiyan, Ph.D., mentors students in research activities at HWCOM. Chinnapaiyan is a member of the Society for Reproductive Biology and Comparative Endocrinology, the Society for Personalized Nano-Medicine, and the American Thoracic Society. He has published several research papers in peer-reviewed scientific journals and has presented his work both nationally and internationally.
Ph.D., Biochemistry-Endocrinology (Interdisciplinary), Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, India
MPhil, Endocrinology, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, India
M.S., Biochemistry, Annamalai University, India
B.Sc., Biochemistry, University of Madras, India
- Junior Research Fellowship in Department of Science and Technology (DST), India
- Senior Research Fellowship in Department of Science and Technology (DST), India
- Edu-GLIA award, an Initial Training Network funded by European Commission under the Seventh Framework Programme, France
Area of Interest/Specialization
His current research predominantly focuses on mucociliary dysfunction in HIV, smoked substance abuse, and the pathophysiological mechanisms that lead to MCC suppression in people living with HIV who also smoke tobacco or abuse illicit drugs. β2-agonists mediated MCC is attenuated in chronic airway diseases (COPD /asthma) and smokers, due to TGF-β mediated suppression of CFTR biogenesis and function. Nevertheless, inhibiting TGF-β signaling can restore CFTR function.
- Chinnapaiyan S, Dutta RK, Devadoss D, Chand HS, Rahman I, Unwalla HJ (2020). Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases. International journal of molecular sciences, 21(8). doi: 10.3390/ijms21083013.
- Chinnapaiyan S, Dutta RK, Nair M, Chand HS, Rahman I, Unwalla HJ (2019). TGF-β1 increases viral burden and promotes HIV-1 latency in primary differentiated human bronchial epithelial cells. Scientific Reports, 9(1):12552. doi: 10.1038/s41598-019-49056-6.
- Dutta RK, Chinnapaiyan S, Rasmussen L, Raju SV, Unwalla HJ (2019). A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-β-Mediated CFTR Expression. Molecular Therapy, 27(2):442-455. doi:10.1016/j.ymthe.2018.11.017. Epub 2018 Dec 6.
- Chinnapaiyan S, Dutta R, Bala J, Parira T, Agudelo M, Nair M, Unwalla HJ (2018). Cigarette Smoke Promotes HIV Infection of Primary Bronchial Epithelium and Additively Suppresses CFTR function. Scientific Reports, 8(1):7984. doi: 10.1038/s41598-018-26095-z.
Agency: Herbert Wertheim College of Medicine Pilot Grant: Improving Airway Health In HIV Associated Lung Co-Morbidities
Role: Principal Investigator
Project Period: 05/01/2020 – 4/30/2022