Dr. Chinnapaiyan Srinivasan received his Ph.D. (2012) in Biochemistry-Endocrinology from the University of Madras, Chennai, India. He was awarded Junior Research Fellowship (2008-2010) and Senior Research Fellowship (2010-2011) in Department of Science and Technology (DST), India, during his Ph.D. He moved to the Prague (2012-2013) as a postdoctoral fellow at the Institute of Experimental Medicine, Department of Molecular Neurophysiology, Czech Republic. He received the Edu-GLIA (PITN-GA-2009-237956) award, an Initial Training Network funded by European Commission under the Seventh Framework Programme (FP7) (2012-2013), France. He worked on DEHP, impairs the insulin signaling and leads to insulin resistance. Avoidance of DEHP may be useful for the prevention of type II diabetes. Moreover, he worked in calcium signaling/imaging and homeostasis in magnocellular neurons and terminals in arginine vasopressin (AVP) and oxytocin (OT) transgenic rat. Currently, he is doing as Postdoctoral Research Associate with Dr. Hoshang Unwalla, Department of Immunology, Florida International University (FIU), USA. His current research predominantly focus on mucociliary dysfunction in HIV and smoked substance abuse and the pathophysiological mechanisms that lead to MCC suppression in people living with HIV who also smoke tobacco or abuse illicit drugs. β2-agonists mediated MCC is attenuated in chronic airway diseases (COPD /asthma) and smokers, due to TGF-β mediated suppression of CFTR biogenesis and function. Nevertheless, inhibiting TGF-β signaling can restore CFTR function. He published several quality research papers in peer reviewed scientific journals and presented his work in many national & international scientific conferences. He is the member of national & international scientific organizations including SRBCE and SPNM.
Chinnapaiyan S, Dutta R, Bala J, Parira T, Agudelo M, Nair M, Unwalla HJ (2018). Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function. Scientific Reports. 8(1):7984. doi: 10.1038/s41598-018-26095-z.
Dutta RK, Chinnapaiyan S, Rasmussen L, Raju SV, Unwalla HJ (2019). A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-β-Mediated CFTR Expression. Molecular Therapy. 27(2):442-455. doi: 10.1016/j.ymthe.2018.11.017. Epub 2018 Dec 6.
- Chinnapaiyan S, Dutta R, Bala J, Parira T, Agudelo M, Nair M, Unwalla HJ (2018). Cigarette Smoke Promotes HIV Infection of Primary Bronchial Epithelium and Additively Suppresses CFTR function. Scientific Reports, 8(1):7984. doi: 10.1038/s41598-018-26095-z.
- Chinnapaiyan S, Parira T, Dutta R, Agudelo M, Morris A, Nair M, Unwalla HJ (2017). HIV Infects Bronchial Epithelium and Suppresses Components of the Mucociliary Clearance Apparatus. PLoS One, 12(1): e0169161.
- Chinnapaiyan S, Unwalla HJ (2015). Mucociliary dysfunction in HIV and smoked substance abuse. Frontiers in Microbiology, 14: 6:1052.
- Dutta RK, Chinnapaiyan S, Rasmussen L, Raju SV, Unwalla HJ (2019). A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-β-Mediated CFTR Expression. Molecular Therapy. 27(2):442-455. doi: 10.1016/j.ymthe.2018.11.017. Epub 2018 Dec 6.
- Srinivasan Chinnapaiyan and Hoshang J. Unwalla, “Mucociliary dysfunction in HIV and smoked substance abuse”, Frontiers in Microbiology, 6 (2015): 1052.
- Chinnapaiyan Srinivasan, et al “Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat”, Toxicology and applied pharmacology, 257 (2011): 155-164.
- Chinnapaiyan Srinivasan and Karundevi Balasubramanian, “Protective effects of antioxidant vitamins against diethyl hexyl phthalate-induced changes in insulin signaling molecules in adult wistar rats”, International Journal of Pharmaceutical & Biological Archives, 4(4) (2013): 1028-1039.
- S Kortus, C Srinivasan, et al “Physiology of spontaneous [Ca 2+] i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus”, Cell calcium, 59 (6) (2016), 280-288.
- Rajesh P, Sathish S, Srinivasan C, et al “Phthalate is associated with insulin resistance in adipose tissue of male rat: role of antioxidant vitamins”, Journal of cellular Biochemistry, 114(3) (2013): 558-569.