Tracey Anne Weiler, Ph.D.
Academic Director for Certificate Program; Associate Professor
Human and Molecular Genetics
Tracey Weiler, Ph.D., is involved in the genetics education of medical students. She is the Academic Director of the Graduate Certificate in Molecular and Biomedical Sciences (GCP), and the course director for GCP courses “Medical Molecular Biology,” and “Medical Genetics”.
She is a member of the Education Committee of the American College of Medical Genetics, the co-chair of the Direct-to-Consumer Genetic Testing Project Group of the Intersociety Coordinating Committee for Practitioner Education in Genetics, and the chair of the AAMC SGEA SIG “Pathways, Pipelines and Bridges”. She has published numerous peer-reviewed papers and presented her work at various national and international conferences.
Her doctoral research focused on limb girdle muscular dystrophy in unique Manitoba populations. Weiler continued her studies at the University of Manitoba where she completed a post-doctoral fellowship in the Manitoba Centre for Proteomics and Systems Biology. During that time, she developed a novel high-throughput protocol for rapid, inexpensive identification of antibody specificity using affinity chromatography and MALDI-MS and MS/MS, collaborated on studies to identify urinary ß2-microglobulin degradation products as bio-markers of chronic kidney transplant rejection and led a team characterizing c19orf10, a novel protein over expressed in the rheumatoid synovium. She then moved to Cincinnati Children’s Hospital Medical Center where her research focused on identification of genes involved in juvenile idiopathic arthritis (JIA) and methotrexate resistance in JIA.
- Ph.D., University of Manitoba, Winnipeg, Canada
- M.Sc, University of Regina, Regina, Canada
- B.Sc, Hons, University of Regina, Regina, Canada
- Innovative Interdisciplinary Strategies in Medical Education
- Population Genetics in South Florida
- Limb Girdle Muscular Dystrophy and Miyoshi Myopathy Genomics
- Kidney Transplant Rejection Proteomics
- Juvenile Idiopathic Arthritis GWAS
- Methotrexate Pharmacogenomics
- Tempest HG, Gillis M, Weiler T, Fortun J. (2016) Design of a platform to discuss ethical considerations of preimplantation genetic diagnosis: A case for integration of ethics in foundational science medical curriculum. Medical Science Educator 26:213-219.
- Nausheen F, Weiler T, Graham D, Lorke DE. Innovative Online Formative Histology Assessment. MedEdPORTAL Publications; 2016. Available from: https://www.mededportal.org/publication/10337
- Hinks A, Moncrieffe H, Martin P, Ursu S, Lal S, Kassoumeri L, Weiler T, Glass DN, Thompson SD, Wedderburn LR, Thomson W. (2011) Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) gene with response to methotrexate in juvenile idiopathic arthritis (JIA). Annals of Rheumatic Disease 70:1395-400.
- Moncrieffe H, Hinks A, Ursu S, Kassoumeri L, Etheridge A, Hubank M, Martin P, Weiler T, Glass DN, Thompson SD, Thomson W, Wedderburn LR. (2010) Generation of novel pharmacogenomic candidates in the response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenetics and Genomics 20:665-76.
- Thompson SD, Ramos PS, Sudman ML, Marion MC, Ryan M, Tsoras MT, Weiler T, Wagner M, Keddache M, Haas JP, Mueller C, Prahalad S, Bohnsack J, Zeft A, Wise C, Punaro M, Rose C, Comeau ME, Divers J, Glass DN, Langefeld CD. (2010) The susceptibility loci Juvenile Idiopathic Arthritis share with other autoimmune diseases extend to PTPN2, COG6 and ANGPT1. Arthritis and Rheumatism 62:3265-76.
- Kocharla L, Taylor T, Weiler T, Ting T, Luggen M, Brunner HI. (2009) Monitoring of Methotrexate Toxicity in Juvenile Idiopathic Arthritis. Journal of Rheumatology. 36:2813-8.
- Weiler T, Dasuri K, Du Q, El-Gabalawy H, Wilkins JA (2007) The identification and characterization of a novel protein, c19orf10, in the rheumatoid synovium. Arthritis Research & Therapy. 9:R30.
- Schaub S, Wilkins JA, Antonovici M, Krokhin O, Weiler T, Rush D, Nickerson P. (2005) Proteomic-Based Identification of Cleaved Urinary beta2-microglobulin as a Potential Marker for Acute Tubular Injury in Renal Allografts. American Journal of Transplantation. 5:729-38.
- Schaub S, Rush D, Wilkins JA, Gibson IW, Weiler T, Sangster K, Nicolle L, Karpinski M, Jeffery J, Nickerson P. (2004) Proteomic-based detection of urine proteins associated with acute renal allograft rejection. Journal of the American Society of Nephrology. 15:219-27.
- Schaub S, Wilkins JA, Weiler T, Sangster K, Rush D, Nickerson P. (2004) Urine protein profiling with surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry. Kidney International 65:323-32.
- Weiler T, Sauder P, Cheng K, Ens W, Standing K, Wilkins JA. (2003) A proteomics-based approach for monoclonal antibody characterization. Analytical Biochemistry. 321:217-25.
- Frosk P, Weiler T, Nylen E, Sudha T, Greenberg CR, Morgan K, Fujiwara TM, Wrogemann K. (2002) Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene. American Journal of Human Genetics. 70:663-72.
- Ashton NW, Champagne CEM, Weiler T, Verkoczy L (2000) The bryophyte, Physcomitrella patens replicates extrachromosomal transgenic elements. New Phytologist 146(3): 391-402.
- Weiler T, Bashir R, Anderson LVB, Davison K, Moss JA, Britton S, Nylen E, Keers S, Vafiadaki E, Greenberg CR, Bushby KMD and Wrogemann K (1999) Identical mutation in patients with limb girdle muscular dystrophy type 2B or Miyoshi myopathy suggests a role for modifier gene(s). Human Molecular Genetics 8:871‑877.
- Weiler T, Greenberg CR, Zelinski T, Nylen E, Coghlan G, Crumley MJ, Fujiwara TM, Morgan K and Wrogemann K (1998) A gene for autosomal recessive limb-girdle muscular dystrophy in Manitoba Hutterites maps to chromosome region 9q31-q33: evidence for another limb-girdle muscular dystrophy locus. American Journal of Human Genetics 63:140-147.
- Weiler T, Greenberg CR, Nylen E, Morgan K, Fujiwara TM, Crumley MJ, Zelinski T, Halliday W, Nickel B, Triggs-Raine B and Wrogemann K (1997) Limb girdle muscular dystrophy in Manitoba Hutterites does not map to any of the known LGMD loci. American Journal of Medical Genetics 72:363-368.
- Weiler T, Greenberg CR, Nylen E, Halliday W, Morgan K, Eggertson D and Wrogemann K (1996) Limb-girdle muscular dystrophy and Miyoshi myopathy in an aboriginal Canadian kindred map to LGMD2B and segregate with the same haplotype. American Journal of Human Genetics 59:872-878.