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Steenackers, Agata, PhD

Title: Visiting Assistant Professor

Office: AHC5 456


Specialty: Glycosylation, cell biology, protein purification, western blot, animal models (mouse)

Department(s): Translational Glycobiology Institute

Agata Steenackers is a visiting assistant professor in the lab of Dr. Robert Sackstein at the Translational Glycobiology Institute at FIU (TGIF).

Education and Training

MS, University of Silesia, Poland
MS, Structural and Functional Glycobiology Unit, University of Lille 1, France
PhD, Biochemistry, Structural and Functional Glycobiology Unit, University of Lille 1, France
Post-doctoral training, Structural and Functional Glycobiology Unit, University of Lille 1, France
Post-doctoral training, National Institutes of Health, Bethesda, MD

Selected Publications

  1. Berthier A, Porez G, Steenackers A, Alexandre J, Yamakawa N, Gheeraert C, Ploton M, Maréchal X, Chevalier-Dubois J, Hovasse A, Schaeffer-Reiss C, Cianferani-Sanglier S, Rolando C, Bray F, Duez H, Eeckhoute J, Lefebvre T, Staels B and Lefebvre P. Combinatorial regulation of cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex. Proc Natl Acad Sci U S A. 2018 Nov 5
  2. Groux-Degroote S, Schulz C, Coger V, Portier L, Vicogne D, Solorzano C, Dall'Olio F, Steenackers A, Mortuaire M, Gonzalez-Pisfil M, Henry M, Foulquier F, Heliot L, and Harduin-Lepers A. The extended cytoplasmic tail of the human β4GALNT2 is critical for its Golgi targeting and post-Golgi sorting. FEBS J. 2018 Sep;285(18):3442-3463
  3. Colomb F, Krzewinski-Recchi MA, Steenackers A, Vincent A, Harduin-Lepers A, Delannoy P, Groux-Degroote S. TNF up-regulates ST3GAL4 and sialyl-LewisX expression in lung epithelial cells through an intronic ATF2 responsive element. Biochem J. 2017, 474(1):65-78
  4. Steenackers A, Olivier-Van Stichelen S, Baldini S, Dehennaut V, Toillon RA, Le Bourhis X, El Yazidi-Belkoura I, Lefebvre T. Physio-pathological properties of colon cells are regulated by the nucleocytoplasmic OGT. Front Endocrinol. 2016,25;7:46.
  5. Steenackers A, Vanbeselaere J, Cazet A, Bobowski M, Rombouts Y, Colomb F, Le Bourhis X, Guérardel Y, Delannoy P. Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase. Molecules. 2012, 17: 9559-72.

View a full list of Steenacker's publications.

Research Areas

Steenacker’s PhD work focuses on understanding how diseases, such as cancer, are associated with dramatic changes in glycan patterns, with a special interest in the relationship between complex ganglioside expression and breast cancer cell proliferation, migration and invasion. After completing her doctorate at the University of Lille, France, she worked as a post-doctoral fellow in the university’s Structural and Functional Glycobiology Laboratory where she focused on O-GlcNAc modifications in colorectal cancer development. 

Her second post-doctoral training was in the Laboratory of Cellular and Molecular Biology at the National Institutes of Health (NIH) in Bethesda, MD. Her research at the NIH focused on determining the full-length structures of the enzymes responsible for O-GlcNAc modifications using cryogenic electron microscopy (cryo-EM). She also worked on different aspects of O-GlcNAcylation, where she developed a liver O-GlcNAcase knockout mouse model. She then employed this to study the impact of O-GlcNAcylation on metabolic syndrome development.