Dr. Myosotys Rodriguez is an Assistant Professor in Dr. Nazira El-Hage laboratory at the Center of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology of Florida International University, Miami, Florida. Dr. Rodriguez obtained her Ph.D. in cellular and molecular biology, with expertise in HIV-1 neuropathology within the context of opioid abuse, from the Universidad Central del Caribe, Puerto Rico. She has worked as a visiting graduate research assistant with the group of Dr. Kurt Hauser at Virginia Commonwealth University, Richmond, Virginia. She has been awarded Early Career Investigator Travel Award (ECITA) for the 22nd and 23nd annual meeting of the Society on Neuroimmune Pharmacology (SNIP). Currently, her research in Dr. Nazira El-Hage laboratory examines the role of autophagy in the pathogenesis of HIV-neurodegenerative disorders. The main goals of her research are:
- To determine whether imbalances in autophagy alter HIV-induced astroglia metabolic dysfunctions and learning impairment.
- To develop effective delivery and on-demand controlled release of siBeclin1 using nanoparticles to attenuate HIV and neuroinflammation in vivo.
- Rodriguez, M., Lapierre, J., Ojha, C.R., Pawitwar, S., Karuppan, M.K.M., Kashanchi, F., El-Hage, N., 2019. Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes. Journal of neurovirology.
- Lapierre, J., Rodriguez, M., Ojha, C.R., El-Hage, N., 2018. Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology.
- Rodriguez, M., Lapierre, J., Ojha, C.R., Estrada-Bueno, H., Dever, S.M., Gewirtz, D.A., Kashanchi, F., El-Hage, N., 2017. Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes. Viruses 9.
- Rodriguez, M., Lapierre, J., Ojha, C.R., Kaushik, A., Batrakova, E., Kashanchi, F., Dever, S.M., Nair, M., El-Hage, N., 2017b. Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. Scientific Reports 7, 1862.
- Rodriguez, M., Kaushik, A., Lapierre, J., Dever, S.M., El-Hage, N., Nair, M., 2017a. Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology 12, 120-132.
Personal Web link: https://www.researchgate.net/profile/Myosotys_Rodriguez