Muthu Karuppan, Mohan Kumar
Title: Postdoctoral Associate
Office: AHC1 320A
Department(s): Immunology and Nano-Medicine
Dr. Mohan Kumar Muthu Karuppan is a postdoctoral research associate in the lab of Dr. Madepali Lakshmana.
His current research is focused on animal models of the Zika virus; trying to understand the pathophysiology of the virus’s infection and transmission from a pregnant mother to the fetus. He is exploring the possible role and impact of autophagy in the Zika virus infection using the Beclin1 knockout autophagy mouse model.
Dr. Muthu Karuppan also works on researching the gender differences in HIV-associated neuropathic pain, the influence of autophagy on wound healing, as well as the intranasal delivery of nanotherapeutics, in HIV animal models. He also works with animal models of Alzheimer’s Disease.
Prior to coming to the U.S., Dr. Muthu Karuppan worked in the pharmaceutical industry in India for 10 years, working on drug discovery and development.
Education and Training
- Postdoctoral fellow at Loma Linda University, Loma Linda, CA
- Ph.D. in Pharmacology from Banaras Hindu University, Varanasi, India
- Master of Science in Pharmaceutical Sciences (Pharmacology) from BITS-Pilani, India
- Bachelor of Science in Pharmaceutical Sciences from The TN Dr. MGR Medical University, Chennai, India
- Animal models of disease
- Neuro-inflammation and animal behavior
- Preclinical Pharmacokinetics (PK-PD)
- Dayang Yasmin Abg Abd Wahab, Chuang Huei Gau, Rahimah Zakaria, Mohan Kumar Muthu Karuppan, Badriya S.A-rahbi, Zuraidah Abdullah, Jafri Malin Abdullah and Sangu Muthuraju. Review on Cross-talk between neurotransmitters and neuroinflammation in striatum and cerebellum in the mediation of motor behavior. BioMed Res International, 2019, 1767203 (PMID: 31815123)
- Ojha CR, Rodriguez M, Muthu Karuppan MK, Lapierre J, Kashanchi F, and El-Hage N. Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLoS One, 2019; 14 (2): e0208543. (PMID: 30735502)
- Rodriguez M, Lapierre J, Ojha CR, Pawitwar S, Muthu Karuppan MK, Kashanchi F and El-Hage N. Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone modifying enzymes in HIV-infected astrocytes. Journal of NeuroVirology,2019; 25 (2): 263 – (PMID-30746609)