Chand, Hitendra Singh
Title: Associate Professor
Office: AHC1 418C
Department(s): Immunology and Nano-Medicine
Dr. Chand received his PhD from the University of Delhi, New Delhi, India while studying the protein chemistry of reproductive hormones and was trained in molecular endocrinology at the Indian Institute of Sciences, Bangalore. The postdoctoral training at the Department of Pathology, UNM Health Science Center, Albuquerque, NM involved identification and characterization of blood coagulation factors and their role the cancer biology. As an Assistant Professor at the Center for Infectious Diseases and Immunology (CIDI), UNM School of Medicine, Dr. Chand worked on systems biology based studies to understand the pathogenesis of opportunistic pulmonary infectious diseases and allergic asthma.
He pursued his interest in the field of Respiratory Biology at the Lovelace Respiratory Research Institute (LRRI), Albuquerque, NM, and investigated the molecular mechanisms involved in the programmed cell death and inflammatory responses using the experimental cell culture and animal models of airway diseases and help translate findings in clinical pathologies. Currently, at the Herbert Wertheim College of Medicine, Dr. Chand is serving as an Associate Professor (tenure-track) in the Department of Immunology and Nano-Medicine and the Center for Personalized Nanomedicine.
Primary research interest involves understanding the mechanisms of Pulmonary and Systemic Inflammation and Lung Tissue Remodeling in Chronic Airway Diseases like Allergic Asthma and COPD. While mucus production is an innate beneficial response, however due to a dysregulation in the underlying mechanisms including the persistent increase in the goblet cell numbers leads to a progressive and fulminant airway obstruction and mucus plugging. In addition, accumulated mucus provides a nutrient-rich niche for microbial infections and inflammation that impedes the lung functions. In this context, we have recently reported that airway epithelium preserve an ‘innate memory’ to help augment a rapid and “trained response” following the secondary challenges. This trained response due to the genetic, epigenetic, metabolomic and signalome remodeling and its interplay with the environmental and biological irritants are being currently investigated in the laboratory.
Primarily the laboratory research involves:
- Investigating the mechanisms of Airway Epithelial Remodeling
- Understanding the role of Long Non-coding RNAs in inflammatory responses
- Role of HIV infection and inhaled substance abuse
- Role of Mitochondrial dynamics in airway diseases
- Personalized Nanomedicine in chronic diseases
- Chand HS, Vazquez-Guillamet R, Royer C, Rudolph K, Mishra N, Singh S, Hussain S, Barrett E, Callen S, Byrareddy S, Vazquez-Guillamet MC, Abukhalaf J, Sheybani A, Exil V, Raizada V, Agarwal H, Nair M, Villunger F, Buch S, and Sopori M. “Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques.” J Clin Invest. 2018 Dec 3;128(12):5428-5433. doi: 10.1172/JCI121935. PMID: 30277472
- Garcia E, Shinde R, Martinez S, Kaushik A, Chand HS, Nair M, Jayant RD. “Cell-Line-Based Studies of Nanotechnology Drug-Delivery Systems: A Brief Review.” Nanocarriers for Drug Delivery 2019, 375-393. https://doi.org/10.1016/B978-0-12-814033-8.00012-6. (A Book Chapter)
- Hussain SS, George S, Singh S, Jayant R, Hu CA, Sopori M, Chand HS. “A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells.” Scientific Reports 2018; 8(1):13796. PMID: 30218002
- Gupta P, Garcia E, Sarkar A, Kapoor S, Rafiq K, Chand HS, Nair M, Jayant RD. “Nanoparticle based treatment for Cardiovascular Diseases.” Cardiovascular & Hematological Disorders Drug Targets. 2018; PMID: 29737265
- Chand HS, Harris JF, Tesfaigzi Y. “IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells.” Scientific Reports 2018 Jan 11;8(1):436. PMID: 29323189
- Zhang C, Jones JT, Chand HS, Wathelet MG, Evans CM, Dickey B, Xiang J, Mebratu YA, Tesfaigzi Y. “Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation.” Mucosal Immunol. 2018 May;11(3):741-751. doi: 10.1038/mi.2017.117. PMID: 29363670
- Chand HS, Mebratu Y, Kuehl PJ and Tesfaigzi Y. “Blocking Bcl-2 Resolves IL-13–Mediated Mucous Cell Hyperplasia in a Bik-Dependent Manner.” J Allergy Clin. Immunol. 2017 Nov; 140(5):1456-1459.e9. PMID: 28784260
- Mebratu YA, Leyva-Baca I, Wathelet MG, Lacey N, Awji EG, Choi AMK, Chand HS, and Tesfaigzi Y. “Bik Enriches Bak at the Endoplasmic Reticulum to Tether Mitochondria for Efficient Calcium Transfer to Reduce Hyperplastic Mucous Cells”. Nature Communications 2017 Oct 6; 8(1):803. PMID: 28986568
- Singh SP, Chand HS, Langley RJ, Mishra N, Barrett T, Rudolph K, Tellez C, Filipczak PT, Belinsky S, Saeed AI, Sheybani A, Exil V, Agarwal H, Sidhaye VK, Sussan T, Biswal S, and Sopori M. “Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia.” J Immunol. 2017 May 15; 198:3815-3822. PMID: 28381639 (Adjudged among top 10% of articles in J. Immunol).
- Jang JH#, Chand HS#, Bruse S, Doyle-Eisele M, Royer C, McDonald J, Qualls C, Klingelhutz AJ, Lin Y, Mallampalli R, Tesfaigzi Y, Nyunoya T. “Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and is Associated with COPD Severity.” COPD 2017 Apr; 14(2):228-237. PMID: 28026993 # Equal Contribution.
- Chand HS*, Mebratu YA, Montera M, Tesfaigzi Y. “T cells Suppress Memory-Dependent Rapid Mucous Cell Metaplasia in Mouse Airways.” Respiratory Research 2016, 17:132. (*Corresponding author). PMID: 27765038
- Mebratu YA, Tipper J, Chand HS, Walton S, Harrod KS, and Tesfaigzi Y. “Bik Mediates Caspase-dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection.” J. Respir. Cell. Mol. Biol. 2016 May;54(5):664-73. PMID: 26437021
- Chand HS, Montano G, Huang X, Randell SC, Petersen H and Tesfaigzi Y. “A variant in the proline-rich domain of p53 restricts the mucus secretory phenotype by regulating SPDEF and Bcl-2 expression.” Nature Communications Nov 27; 5:5567. PMID: 25429397
- Nyunoya T, Mebratu Y, Contreras A, Delgado-Vargas M, Chand HS and Tesfaigzi Y. “Molecular Processes that Drive Cigarette Smoke-Induced Effects on Epithelial Cells of the Lung.” J. Resp. Cell Mol. Biol. 2014; 50(3):471-82. PMID: 24111585
- Chand HS*, Schuyler M, Joste N, Hensler C, Tesfaigzi Y, Masten B, Schrader R and Lipscomb MF. “Anti-IgE Therapy Results in Decreased Myeloid Dendritic Cells in Asthmatic Airway” J Allergy Clin. Immunol. 2010; 125(5):1157-1158. PMID: 22878411
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