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Rosen, Barry Philip

Title: Distinguished University Professor

Office: AHC1 419D

Phone: 305-348-0657


Curriculum Vitae

Department(s): Cellular Biology and Pharmacology

Barry P. Rosen is currently Distinguished University Professor at the Herbert Wertheim College of Medicine, Florida International University in Miami, Florida since 2009. He was Associate Dean for Basic Research and Graduate Programs from 2009-2016. For 22 years he was Chair and Distinguished Professor of Biochemistry and Molecular Biology at Wayne State University School of Medicine in Detroit, Michigan. He received his B.S. from Trinity College, Hartford, Connecticut in 1965 and his M.S. (1968) and Ph.D. (1969) from the University of Connecticut and was an NIH postdoctoral fellow at Cornell University (1969-1971). He was on the faculty at the University of Maryland School of Medicine in Baltimore, Maryland for 15 years. For nearly four decades his laboratory has investigated the mechanisms of transport and detoxification of transition metals, heavy metals and metalloids in bacteria, yeast, protozoans, mammals and plants. He identified the pathways of arsenic uptake, efflux, biotransformation and regulation in organisms fromE. colito humans. He identified most of the known arsenic detoxification genes and characterized their gene products at the biochemical and structural level. He solved the crystal structure of the ArsA As(III)-translocating ATPase, the ArsR repressor orthologue CadC, the ArsC and LmAcr2 arsenate reductases, the ArsH NADPH-FMN oxidoreductase, the ArsD As(III) metallochaperone, the ArsM As(III)-SAM methyltransferases fromCyanidioschyzon merolae and Chlamydomonas reinhardtiiand most recently the ArsI C-As lyase. He identified and named the ArsR family of metalloregulatory proteins. He made the seminal discovery that aquaglyceroporin channels, fromE. coliGlpF to human AQP9, are the transporters that nearly every cell uses to take up As(III). He is currently elucidating the enzymes and transporters of the arsenic biomethylation and organoarsenical redox cycles. He has published more than 320 papers, reviews and books and is the holder of a prestigious MERIT Award from the National Institute of Health. He is recipient of numerous awards, including Basil O'Connor Award from the March of Dimes, Maryland Distinguished Young Scientist Award, Josiah Macy, Jr. Faculty Scholar Award, Gershenson Distinguished Faculty Fellow Award (WSU), Outstanding Graduate Mentor Award (WSU) and Lawrence Weiner Medical Alumni Award (WSU) and is an elected fellow of both the American Association for the Advancement of Science (AAAS) and the American Society for Microbiology (ASM). He has been on many national and international panels at NIH, NSF, and American Heart Association, and on multiple editorial boards. He has served as both President of the Wayne State University Academy of Scholars and President of the Association of Medical and Graduate Departments of Biochemistry. He most recently was a reviewer of the FDA policy on arsenic in rice.

Research Interests:
Pathways of arsenic uptake and detoxification (NIH Grant R37 GM55425)
The overall goal of research in the Rosen laboratory is a detailed molecular analysis of the arsenic transporters and modifying enzymes.Arsenic, a Group 1 human carcinogen, ranks first on the EPA's Superfund list. Arsenic enters the human body from both geological and anthropogenic sources. Because of the ubiquity of arsenic in the environment, every organism has developed transport systems for the efflux and detoxification of arsenic. Chronic exposure to arsenic has been linked to cardiovascular and peripheral vascular diseases, neurological disorders, diabetes and various cancers. Arsenic-containing drugs are used as chemotherapeutic agents for the treatment of leukemia and parasitic diseases. An understanding of both arsenic chemistry and the molecular details of arsenic transport systems is essential for alleviating the problems of arsenic toxicity, as well as for the rational design of drugs to treat drug-resistant microbes and cancer cells.

Selected recent publications (from more than 260 articles, chapters and books):

  1. Zhu YG, Xue XM, Kappler A, Rosen BP, Meharg AA. Linking Genes to Microbial Biogeochemical Cycling: Lessons from Arsenic. Environ Sci Technol. in press (2017
  2. Hao, X., Li, X., Pal, C., Hobman, J., Larsson, D.G., Saquib, Q., Alwathnani, H.A., Rosen, B.P., Zhu, Y.G., Rensing, C. Bacterial resistance to arsenic protects against protist killing. Biometals. 30,307-311 (2017). PMID: 28210928
  3. Chen, J., Li, J., Jiang, X. and Rosen B.P. Conserved cysteine residues determine substrate specificity in a novel As(III) S-adenosylmethionine methyltransferase from Aspergillus fumigatus. Mol Microbiol. 104, 250-259 (2017). PCMID: PMC5380552
  4. Chen, J. and Rosen, B.P. Organoarsenical biotransformations by Shewanella putrefaciens. Environ Sci Technol. 50,7956-7963(2016). PCMID: PCM27366920
  5. Yang, H.C. and Rosen, B.P. New mechanisms of bacterial arsenic resistance. Biomed. J. 39,5-13(2016). PMID 27105594
  6. Huang, K., Chen, C., Zhang. J., Tang, Z., Shen, Q., Rosen, B.P. and Zhao, F.J. Efficient arsenic methylation and volatilization mediated by a novel bacterium from an arsenic-contaminated paddy soil. Sci. Technol.  50, 6389-6396(2016). PCMID: PCM27258163
  7. Li, J., Mandal, G. and Rosen, B.P. Expression of arsenic resistance genes in the obligate anaerobe Bacteroides vulgatus ATCC 8482, a gut microbiome bacterium. Anaerobes, 39,117-123(2016). PCMID: PMC4984537
  8. Chen, J., Yoshinaga, M., Garbinski, L. and Rosen, B.P. Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance. Molec. Microbiol. 100,945-953 (2016). Accompanied by microcommentary. PCMID: PMC4992400
  9. Nadar, V.S., Yoshinaga, M., Pawitwar, S., Kandavelu, P., Sankaran, B. and Rosen, B.P. Structure of the ArsI C-As lyase: insights into the mechanism of degradation of organoarsenical herbicides and growth promoters. Molec. Biol. 428, 2462–2473 (2016). PCMID: PCM27107642
  10. Tang, Z., Lv, Y., Chen, F., Zhang,W., Rosen, B.P. and Zhao, F.G. Arsenic methylation in Arabidopsis thaliana expressing an algal arsenite methyltransferase gene increases arsenic phytotoxicity. J. Agric. Food Chem. 64, 2674–2681. PMCID: PMC4984539
  11. Duan, G. Hu, Y., McDermott, J., Chen, J., Schneider, S., Saur, N. Rosen, B.P., Liu, Z. and Zhu, Y.G. Inositol permeases AtINT2 and AtINT4 transport arsenic into Arabidopsis thaliana Nature Plants, 21,15202(2016). Carried by many international news feeds. PMCID: PMC4758254
  12. Kumar, N.V., Yang. J., Pillai, J.K., Rawat, S., Solano, C. Kumar, A., Grøtli, M., Stemmler, T.L., Rosen, B.P., Tamás, M.J. Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8, Cell. Biol. 36, 913-922 (2015). PCMID: PMC4810476
  13. Dong, H., Madegowda. M., Nefzi, A., Houghten, R.A., Giulianotti, M.A. and Rosen, B.P. Identification of small molecule inhibitors of human As(III) S-adenosylmethionine methyltransferase (AS3MT). Chem. Res. Toxicol. 21, 2419-2425 (2015). Editors’ Choice Paper.

Books and Chapters

  1. Walmsley, A.R. and Rosen, B.P. Efflux mechanisms in drug resistance. In Antimicrobial Drug Resistance, Douglas L. Mayers, editor, Humana Press, in press (2008).
  2. Rensing, C. and Rosen, B.P. Heavy metal cycles. In Encyclopedia of Microbiology, Third Edition, Moselio Schaechter, Editor-in-Chief, Elsevier, in press (2008).
  3. Rosen, B.P. and Liu, Z. Transport pathways for arsenic and selenium. Environmental International., Sunbaek Bang, Editor. Transport pathways for arsenic and selenium: A minireview in press (2008).
  4. Liu, Z. and Rosen, B.P. Uptake pathways for arsenic and selenium. Proceedings of the XIIIth Annual Meeting of All India Congress of Cytology and Genetics, A. Giri, Editor, in press (2008).
  5. Bhattacharjee, H., Mukhopadhyay, R. and Rosen, B.P. Aquaglyceroporins: ancient channels for metalloids. J. Biol. 7, 33 (2008).
  6. Bhattacharjee, H., Rosen, B.P. and Mukhopadhyay, R., Metalloid transport by aquaglyceroporins.In Handbook of Experimental Pharmacology, Eric Beitz, Editor, 190, 309-325(2009).
  7. Rosen, B.P. and Tamás, M.J. Arsenic transport in prokaryotes and eukaryotic microbes, in MIPs (major intrinsic proteins) and their role in the exchange of metalloids, Thomas Jahn and Gerd Patrick Bienert, editors, Landes Bioscience Publishers, In press (2009).