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Madhavan Nair, PhD

Title
Distinguished Professor and Founding Chair, Dept of Immunology, Director, Institute of Neuro-Immune Pharmacology, FIU College of Medicine Associate Dean, Bio. Med. Res, Florida International University
Office
AHC-1 418A
Phone
305-348-1493
Email
madhavan.nair@fiu.edu
Biography


Madhavan Nair, PhD received his PhD from Tata Memorial Cancer Center, Bombay University, India in Cancer Immunology and trained at Memorial Sloan Kettering Cancer Center, New York City. He then joined the faculty of the Department of Pediatrics at University of Michigan, Ann Arbor and subsequently worked at the Department of Medicine and Microbiology at SUNY, Buffalo, NY as a Tenured Professor and Director of Research in Allergy and Immunology. He is a certified Clinical Nutrition Specialist (CNS), Fellow of American College of Nutrition (FACN) and Fellow of American Academy of Allergy, Asthma and Immunology (FAAAI).

Nair and his colleagues discovered the suppressor factor in cancer serum (1978) and first reported that intravenous drug users manifest low natural killer cell activity (1986) and morphine induces apoptosis of normal lymphocytes (1997). In 1988, Dr Nair reported for the first time (PNAS) that HIV recombinant purified gene products possess significant biological activities. His original discovery that cocaine increases the sensitivity to HIV infection by increasing the HIV co-receptors and methamphetamine exacerbates the HIV replication in dendritic cells had a profound effect on the role of these drugs on HIV disease progression. His recent research mainly involves the role of different drugs of abuses such as alcohol, morphine, cocaine and methamphetamine on neuro-AIDS and therapeutic approach to control Neuro-AIDS by specific drug targeting to brain using nanotechnology.

Nair is the first FIU researcher to earn a prestigious MERIT Award from the National Institutes of Health recognizing outstanding competence and productivity in research (2008-2018). Nair is also the recipient of University of Michigan Distinguished Research Scientist Award (1990), Exceptional Research Scholar Award from State University of New York (2005), Excellence in Faculty Scholarship Award from FIU (2008) and Presidential Leadership Operational Excellence Award from FIU in 2009.

Nair has published more than 100 papers as first and/or senior author, mentored more than 50 undergraduate, graduate, postdoctoral fellows, high school and minority students, served in various committees, organized various national and international conferences, chaired number of scientific sessions and served in various NIH study sections committees as chair/ member since 1980. His research is currently supported with four major NIH grants.

Research Interest:

Dr. Nair and his colleagues discovered the suppressor factor in cancer serum (1978) and first reported that intravenous drug users manifest low natural killer cell activity (1986) and morphine induces apoptosis of normal lymphocytes (1997). In 1988, Dr. Nair reported for the first time (PNAS) that HIV recombinant purified gene product possess significant biological activities. His original reports that cocaine increases the sensitivity to HIV infection by increasing the HIV co-receptors and methamphetamine exacerbates the HIV replication in dendritic cells had a profound effect on the role of these drugs on HIV disease progression. His recent research mainly involves the role of different drugs of abuses such as alcohol, morphine, cocaine and methamphetamine on neuro-AIDS and therapeutic approach to control Neuro-AIDS by specific drug targeting to brain using nanotechnology. Dr. Nair is the first FIU researcher to earn a prestigious MERIT Award from the National Institutes of Health recognizing outstanding competence and productivity in research (2008-2018). Dr. Nair is also the recipient of University of Michigan Distinguished Research Scientist Award (1990), Exceptional Research Scholar Award from State University of New York (2005), Excellence in Faculty Scholarship Award from FIU (2008), Presidential Leadership Operational Excellence Award from FIU in 2009 and FIU's Top Research Scholar Award in 2010. Dr. Nair has published more than 100 papers as first and/or senior author, mentored more than 50 undergraduate, graduate, postdoctoral fellows, high school and minority students, served in various committees, organized various national and international conferences, chaired number of scientific sessions and served in various NIH study sections committees as chair/ member since 1980. His research is currently supported with four major NIH grants.

Recent publications:

  • Saxena SK, Shrivastava G , Tiwari S, Nair MPN. (2012) HIV-1 Nef: hacker of the host cell. Future Virology, 7(2) 117-120.

  • Pilakka-Kanthikeel S, Saiyed ZM, Napuri J, Nair MP. (2011) MicroRNA: implications in HIV, a brief overview. J. Neurovirol. (5):416-23.

  • Reddy PV, Gandhi N, Samikkannu T, Saiyed Z, Agudelo M, Yndart A, Khatavkar P, Nair MP. (2011) HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: Role in HIV associated neurocognitive disorder. Neurochem Int. (Epub ahead of print).

  • Samikkannu T, Agudelo M, Gandhi N, Reddy PV, Saiyed ZM, Nwankwo D, Nair MP. (2011). Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS. J. Neurovirol. 17(3):230-8.

  • Agudelo, M, Gandhi, N, Saiyed, Z, Pichili, V, Samikkannu, T ,Khatavkar P, and Nair MP.(2011). Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). Alcohol. Clin. Exp. Res. 35(8):1550-6.

  • Nair MP, Saiyed ZM. (2011) Effect of methamphetamine on expression of HIV coreceptors and CC-chemokines by dendritic cells. Life Sci. 88(21-22):987-94.

  • Nair MP and Saiyed ZM. (2011) Chapter 11: Antiretroviral and Adjunctive Therapies. 11.5 Antiretroviral nanotherapies. Eds. Gendelman HE, Everall IP, Fox H, Gelbard H, Grant I, Lipton S, Swindells S. The Neurology of AIDS. 3rd Edition. (pp 1160). Oxford University Press Inc. ISBN13: 978-0-19-539934-9.

  • Agudelo, M, Saiyed, Z, Samikkannu, T, Khatavkar P, Gandhi, N, Nair N, and Nair MP. (2010). Dendritic Cells: Types, Life Cycles and Biological Functions. Chapter 10: Role of Dendritic Cells in HIV Infection: DC-SIGN and Novel Therapeutic Approaches. Nova Publishers. 167-177.

  • Samikkannu T, Rao KV, Gandhi N, Saxena SK, Nair MP. (2010). Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS. J Neurovirol. 16(4):255-63.

  • Gandhi N, Saiyed ZM, Napuri J, Samikkannu T, Reddy PV, Agudelo M, Khatavkar P, Saxena SK, Nair MP. (2010). Interactive Role of HIV-1 Clade Specific Tat Protein and Cocaine in Blood-Brain Barrier Dysfunction: Implications for HAND. J. Neurovirol. 16(4):294-305.

  • Saiyed ZM, Gandhi NH, Nair MPN. (2010). Magnetic nanoformulation of Azidothymidine 5'-triphosphate for targeted delivery across the blood-brain barrier. Int. J. Nanomed. 5: 157-166.

  • Míguez MJ, Lewis JE, Bryant VE, Rosenberg R, Burbano X, Fishman J, Asthana D, Duan R, Madhavan N, Malow RM. (2010). Low cholesterol? Don't brag yet ... hypocholesterolemia blunts HAART effectiveness: a longitudinal study. J Int AIDS Soc. 13:25.