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Barry P Rosen, PhD

Associate Dean for Basic Research and Graduate Programs, Office of Academic Affairs; Professor, Department of Cellular Biology and Pharmacology
AHC2 673A

Barry P. Rosen joined the FIU College of Medicine from Wayne State University School of Medicine, where he is Distinguished Professor of Biochemistry and Molecular Biology and Chair of the Department. Dr. Rosen received his B.S. from Trinity College, Hartford, CT and his M.S. and Ph.D. from the University of Connecticut.

After an NIH postdoctoral fellow at Cornell University, he joined the faculty at the University of Maryland School of Medicine, where he rose to Professor.

In 1987 he took the Chair at Wayne State, and under his stewardship the Department of Biochemistry and Molecular Biology took the lead in structural biology at Wayne State University.

Professor Rosen is an internationally recognized expert in the field of heavy metal transport and detoxification, specializing in the molecular mechanisms of arsenic detoxification. He has published more than 300 papers, reviews and books and is the holder of two grants from the National Institute of Health. He is recipient of numerous awards, including Basil O'Connor Award from the March of Dimes, Maryland Distinguished Young Scientist Award, Josiah Macy, Jr. Faculty Scholar Award, Gershenson Distinguished Faculty Fellow Award (WSU), Outstanding Graduate Mentor Award (WSU), Lawrence Weiner Award (WSU).

He has been on many national and international panels at NIH, NSF, and American Heart Association, and on multiple editorial boards. Dr. Rosen was recently selected to be a Distinguished University Professor, the highest honor awarded to a Wayne State University faculty member. He was President of the Wayne State University Academy of Scholars and President of the American Association of Medical and Graduate Departments of Biochemistry until his move to FIU.

Research Interests:
Pathways of arsenic uptake and detoxification (NIH Grant R37 GM55425)
The overall goal of research in the Rosen laboratory is a detailed molecular analysis of the arsenic transporters and modifying enzymes.Arsenic, a Group 1 human carcinogen, ranks first on the EPA's Superfund list. Arsenic enters the human body from both geological and anthropogenic sources. Because of the ubiquity of arsenic in the environment, every organism has developed transport systems for the efflux and detoxification of arsenic. Chronic exposure to arsenic has been linked to cardiovascular and peripheral vascular diseases, neurological disorders, diabetes and various cancers. Arsenic-containing drugs are used as chemotherapeutic agents for the treatment of leukemia and parasitic diseases. An understanding of both arsenic chemistry and the molecular details of arsenic transport systems is essential for alleviating the problems of arsenic toxicity, as well as for the rational design of drugs to treat drug-resistant microbes and cancer cells.

Selected recent publications (from more than 260 articles, chapters and books):

  1. Ye, J., Rensing, C., Rosen, B.P. and Zhu, Y.G., Arsenic biomethylation by photosynthetic organisms. Trends Plant Sci. 17, 155-162 (2012).

  2. Marapakala, K., Qin, J. and Rosen, B.P. Identification of catalytic residues in the As(III) S-adenosylmethionine methyltransferase. Biochemistry 51, 944-951(2012).

  3. Santha, S., Pandaranayaka, E.P.J., Rosen, B.P. and Thiyagarajan, S. Purification, crystallization and preliminary X-ray diffraction studies of the arsenic repressor ArsR from Corynebacterium glutamicum. Acta Cryst. F67, 1616–1618, (2011).

  4. Rosen, B.P., Ajees, A.A. and McDermott, T.R. Life and death with arsenic: Arsenic life: An analysis of the recent report "A bacterium that can grow by using arsenic instead of phosphorus" BioEssays 33, 350-357(2011).

  5. Yin, X.X., Chen, J., Qin, J., Sun, G.X., Rosen, B.P. and Zhu, Y.G. Biotransformation and volatilization of arsenic by three photosynthetic cyanobacteria. Plant Physiol. 156(3):1631-168(2011).

  6. Meng, X.Y.. Qin, J., Wang, L.H., Duan, G.L., Sun, G.X., Chu,C.C., Ling, H.Q.. Rosen, B.P. and Zhu, Y.G. Arsenic biotransformation and volatilization in transgenic rice. New Phytologist 191, 49-56 (2011).

  7. Yoshinaga, M., Cai, Y. and Rosen, B.P. Demethylation of methylarsonic acid by a microbial community. Environ. Microbiol 13, 1205-1215 (2011).

  8. Yang, J., Abdul Ajees, A. and Rosen, B.P. Genetic mapping of the interface between the ArsD metallochaperone and the ArsA ATPase. Molec. Microbiol. 79, 872-878 (2011). (Selected for journal cover)

  9. Abdul Ajees, A, Yang, J. and Rosen, B.P. The ArsD As(III) metallochaperone. Biometals 24, 391-399 (2011).

  10. Ye, J., He, Y., Skalicky, J., Rosen, B.P. and Stemmler, T.L. Resonance assignments and secondary structure prediction of the As(III) metallochaperone ArsD in solution. Biomol NMR Assign. 5,109-112 (2011).

  11. Fu, H.L., Rosen B.P. and Bhattacharjee, H. Biochemical characterization of a novel ArsA ATPase complex from Alkaliphilus metalliredigens QYMF. FEBS Lett. 584, 3089-3094 (2010).

  12. Ye, J., Ajees, A.A., Yang, J. and Rosen, B.P. The 1.4 Å crystal structure of the ArsD arsenic metallochaperone provides insights into its interaction with the ArsA ATPase. Biochemistry 49, 5206-5212 (2010).

  13. Jiang, X., McDermott, J., Abdul Ajees, A., Rosen, B.P. and Liu, Z. Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1. Metallomics 2, 211-219 (2010).

  14. Liu, Z., Sanchez, M., Jiang, X., Boles, E., Landerfear, S. and Rosen, B.P. Mammalian glucose transporter GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem. Biophys. Res. Commun. 351,424–430(2006).

  15. McDermott J., Rosen, B.P. and Liu Z. Jen1p: A high affinity yeast selenite transporter. Mol Biol Cell. 21,3934-3941 (2010).

  16. Yang, J., Rawat, S., Stemmler, T.L. and Rosen, B.P. Arsenic binding and transfer by the ArsD As(III) metallochaperone. Biochemistry 49, 3658-3666 (2010).

  17. Fu, H.L., Abdul Ajees, A., Rosen, B.P. and Bhattacharjee, H., Role of signature lysines in the deviant Walker A motif of the ArsA ATPase. Biochemistry 49, 356-364(2010).

  18. Marapakala, K., Abdul Ajees, A., Qin, J., Sankaran, B. and Rosen, B.P. Crystallization and preliminary X-ray crystallographic analysis of the ArsM As(III) S-adenosylmethionine methyltransferase. Acta Crystallographica Section F, Structural Biology and Crystallization Communications, 66, 1050-1052 (2010).

  19. Hamdi, M., Sanchez, M.A, Beene, L.C., Liu, Q., Landfear, S.M., Rosen, B.P. and Liu, Z. Arsenic transport by zebrafish aquaglyceroporins. BMC Molecular Biology 10:104-115 (2009).

  20. McDermott, J.R., Jiang, X., Beene, L.C., Rosen, B.P. and Liu, Z. Pentavalent methylated arsenicals are substrates of human AQP9. Biometals 23, 119-127 (2009).

  21. Fu, H.-L., Meng, Y., Ordóňez, E., Villadangos, A.F., Bhattacharjee, H., Gil, J.A., Mateos, L.M. and Rosen, B.P. Properties of arsenite efflux permeases (Acr3) from Alkaliphilus metalliredigens and Corynebacterium glutamicum. J. Biol. Chem. 284, 19887-19895. (2009).

  22. Carbrey, J.M, Song, L., Zhou, Y., Yoshinaga, M., Rojek, A., Wang, Y., Liu, Y., Lujan, H.L., DiCarlo, S.E., Nielsen, S., Rosen, B.P., Agre, P. and Mukhopadhyay, R. Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. Proc Natl Acad Sci USA 106, 15956-15960 (2009).

  23. Qin, J., Lehr, C.R., Yuan, C. Le, X.C., McDermott, T.R. and Rosen, B.P. Biotransformation of arsenic by a Yellowstone thermoacidophilic eukaryotic alga. Proc. Natl. Acad. Sci. USA, 106, 5213-5217 (2009). (reported in PNAS News and Views).

Books and Chapters

  1. Walmsley, A.R. and Rosen, B.P. Efflux mechanisms in drug resistance. In Antimicrobial Drug Resistance, Douglas L. Mayers, editor, Humana Press, in press (2008).

  2. Rensing, C. and Rosen, B.P. Heavy metal cycles. In Encyclopedia of Microbiology, Third Edition, Moselio Schaechter, Editor-in-Chief, Elsevier, in press (2008).

  3. Rosen, B.P. and Liu, Z. Transport pathways for arsenic and selenium. Environmental International., Sunbaek Bang, Editor. Transport pathways for arsenic and selenium: A minireview in press (2008).

  4. Liu, Z. and Rosen, B.P. Uptake pathways for arsenic and selenium. Proceedings of the XIIIth Annual Meeting of All India Congress of Cytology and Genetics, A. Giri, Editor, in press (2008).

  5. Bhattacharjee, H., Mukhopadhyay, R. and Rosen, B.P. Aquaglyceroporins: ancient channels for metalloids. J. Biol. 7, 33 (2008).

  6. Bhattacharjee, H., Rosen, B.P. and Mukhopadhyay, R., Metalloid transport by aquaglyceroporins.In Handbook of Experimental Pharmacology, Eric Beitz, Editor, 190, 309-325(2009).

  7. Rosen, B.P. and Tamás, M.J. Arsenic transport in prokaryotes and eukaryotic microbes, in MIPs (major intrinsic proteins) and their role in the exchange of metalloids, Thomas Jahn and Gerd Patrick Bienert, editors, Landes Bioscience Publishers, In press (2009).